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抗真菌药物治疗儿童系统性真菌感染。

Antifungal agents for the treatment of systemic fungal infections in children.

出版信息

Can J Infect Dis Med Microbiol. 2010 Winter;21(4):e116-21. doi: 10.1155/2010/784549.

Abstract

Traditionally, the mainstay of systemic antifungal therapy has been amphotericin B deoxycholate (conventional amphotericin B). Newer agents have been developed to fulfill special niches and to compete with conventional amphotericin B by virtue of having more favourable toxicity profiles. Some agents have displaced conventional amphotericin B for the treatment of specific fungal diseases. For example, voriconazole has emerged as the preferred treatment for invasive pulmonary aspergillosis. This notwithstanding, conventional amphotericin B remains a useful agent for the treatment of paediatric fungal infections. Knowledge of the characteristics of the newer agents is important, given the increasing numbers of patients who are being treated with these drugs. Efforts need to be directed at research aimed at generating paediatric data where these are lacking. The antifungal agents herein described are most often used as monotherapy regimens because there is no uniform consensus on the value of combination therapy, except for specific scenarios.

摘要

传统上,系统抗真菌治疗的主要药物是两性霉素 B 去氧胆酸盐(普通两性霉素 B)。为了满足特殊需求并凭借更有利的毒性特征与普通两性霉素 B 竞争,已经开发出了一些新型药物。一些药物已经取代了普通两性霉素 B 用于治疗特定的真菌感染疾病。例如,伏立康唑已成为治疗侵袭性肺曲霉病的首选药物。尽管如此,普通两性霉素 B 仍然是治疗儿科真菌感染的有效药物。鉴于越来越多的患者正在使用这些药物,了解新型药物的特点非常重要。需要努力开展旨在生成儿科数据的研究,而在这些数据缺乏的情况下。本文所述的抗真菌药物通常用作单一疗法方案,因为除了特定情况外,对于联合治疗的价值尚无统一共识。

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