创造超越天然字母表的新型蛋白质序列。
Creating novel protein scripts beyond natural alphabets.
作者信息
Kumar Anil, Ramakrishnan Vibin
出版信息
Syst Synth Biol. 2010 Dec;4(4):247-56. doi: 10.1007/s11693-011-9068-5. Epub 2011 Mar 1.
Abstract
Natural proteins are concatenated amino acids with definite handedness or chirality, with their spatial orientation being preferentially left handed or L-chiral. This paper discusses the biophysics of stereo-chemical perturbation to proteins using D-(α) amino acid and its utility as an additional design alphabet while scripting novel protein structures.
摘要
天然蛋白质是由具有特定手性或旋光性的氨基酸连接而成，其空间取向优先为左旋或L-手性。本文讨论了使用D-（α）氨基酸对蛋白质进行立体化学扰动的生物物理学及其在构建新型蛋白质结构时作为额外设计字母表的用途。
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