Park Jun Yeong, Kwon Won Joo, Park Bok Won, Cho Eun Byul, Park Eun Joo, Kim Kwang Ho, Kim Kwang Joong
Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
Ann Dermatol. 2017 Dec;29(6):776-778. doi: 10.5021/ad.2017.29.6.776. Epub 2017 Oct 30.
A 4-month-old infant presented with asymptomatic soft nodules on his right forearm, which had developed since birth. On the suspicion of nevus lipomatosus superficialis (NLS), biopsy was performed. Histopathologic findings showed monomorphic polygonal cells with abundant granular cytoplasm. Immunohistochemical stains for CD68 and vimentin were strongly positive, but were negative for S-100 protein. Based on the pathologic findings, the patient was diagnosed as non-neural granular cell tumor (NN-GCT). GCT can be divided into conventional and non-neural GCT by immunoreactivity for S-100 protein. NN-GCT is typically manifested as a well-circumscribed, papulo-nodular dermal mass, and is known to occur in a younger group than does in conventional GCT, but is rare among children. To our knowledge, there have been no case reports of NN-GCT which appeared at birth and presented as grouped nodules. Therefore, we report this interesting case of congenital NN-GCT clinically mimicking NLS.
一名4个月大的婴儿右前臂出现自出生以来就有的无症状软性结节。因怀疑为浅表性脂肪瘤样痣（NLS），遂进行了活检。组织病理学检查结果显示为具有丰富颗粒状细胞质的单形性多边形细胞。CD68和波形蛋白的免疫组织化学染色呈强阳性，但S-100蛋白染色为阴性。根据病理结果，该患者被诊断为非神经颗粒细胞瘤（NN-GCT）。颗粒细胞瘤可根据对S-100蛋白的免疫反应性分为传统型和非神经型颗粒细胞瘤。NN-GCT通常表现为边界清楚的丘疹结节状真皮肿物，已知其发病年龄比传统颗粒细胞瘤患者更年轻，但在儿童中较为罕见。据我们所知，尚无出生时出现且表现为成组结节的NN-GCT病例报告。因此，我们报告了这例临床上酷似NLS的先天性NN-GCT的有趣病例。
