Molecular Membrane Biology Laboratory, RIKEN Advanced Science Institute, Wako, Saitama, 351-0198, Japan.
Traffic. 2012 Apr;13(4):505-10. doi: 10.1111/j.1600-0854.2011.01316.x. Epub 2011 Dec 27.
The Golgi apparatus is an organelle that has been extensively studied in the model eukaryote, yeast. Its morphology varies among yeast species; the Golgi exists as a system of dispersed cisternae in the case of the budding yeast Saccharomyces cerevisiae, whereas the Golgi cisternae in Pichia pastoris and Schizosaccharomyces pombe are organized into stacks. In spite of the different organization, the mechanism of trafficking through the Golgi apparatus is believed to be similar, involving cisternal maturation, in which the resident Golgi proteins are transported backwards while secretory cargo proteins can stay in the cisternae. Questions remain regarding the organization of the yeast Golgi, the regulatory mechanisms that underlie cisternal maturation of the Golgi and transport machinery of cargo proteins through this organelle. Studies using different yeast species have provided hints to these mechanisms.
高尔基体是一种细胞器,在模式真核生物酵母中得到了广泛研究。其形态在不同的酵母物种中有所不同;在出芽酵母酿酒酵母中,高尔基体作为分散的潴泡系统存在,而在毕赤酵母和裂殖酵母中,高尔基体潴泡则被组织成堆叠。尽管组织方式不同,但通过高尔基体的运输机制被认为是相似的,涉及潴泡成熟,其中驻留的高尔基体蛋白向后运输,而分泌货物蛋白可以留在潴泡中。关于酵母高尔基体的组织、高尔基体潴泡成熟的调控机制以及货物蛋白通过该细胞器的运输机制仍存在问题。使用不同酵母物种的研究为这些机制提供了线索。