Tip110 维持人类胚胎干细胞中的多能因子表达和多能性。
Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells.
机构信息
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
出版信息
Stem Cells Dev. 2012 Apr 10;21(6):829-33. doi: 10.1089/scd.2011.0512. Epub 2012 Jan 26.
Abstract
HIV-1 Tat-interacting protein of 110 kDa [Tip110; p110(nrb)/SART3/p110] is an RNA binding nuclear protein implicated in regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. Recently, we demonstrated a role for Tip110 in regulation of hematopoiesis. Here, we show that TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs. TIP110 was found, through up- and down-modulation of expression of Tip110, to be important in maintaining pluripotent factor (NANOG, OCT4, and SOX2) expression in and pluripotency of hESCs, although the mechanisms involved and whether the Tip110 effects are direct remain to be determined.
摘要
HIV-1 转录激活蛋白 110kDa 相互作用蛋白（Tip110；p110(nrb)/SART3/p110）是一种 RNA 结合核蛋白，参与调节 HIV-1 基因和宿主基因转录、前体 mRNA 剪接以及癌症免疫学。最近，我们证明了 Tip110 在调节造血中的作用。在这里，我们显示 Tip110 也在人胚胎干细胞（hESCs）中表达，并且随着这些 ESCs 的分化，其表达减少。通过上调和下调 Tip110 的表达，发现 TIP110 对于维持 hESCs 中的多能因子（NANOG、OCT4 和 SOX2）表达和多能性很重要，尽管涉及的机制以及 Tip110 作用是否直接仍有待确定。
相似文献
1
Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells.
Stem Cells Dev. 2012 Apr 10;21(6):829-33. doi: 10.1089/scd.2011.0512. Epub 2012 Jan 26.
2
C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells.
Stem Cells Dev. 2013 Mar 1;22(5):689-94. doi: 10.1089/scd.2012.0271. Epub 2012 Dec 12.
3
TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC.
Blood. 2011 May 26;117(21):5643-51. doi: 10.1182/blood-2010-12-325332. Epub 2011 Mar 29.
4
Tip110: Physical properties, primary structure, and biological functions.
Life Sci. 2016 Mar 15;149:79-95. doi: 10.1016/j.lfs.2016.02.062. Epub 2016 Feb 16.
5
Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2.
Stem Cells. 2017 Jul;35(7):1674-1686. doi: 10.1002/stem.2631. Epub 2017 May 7.
6
Role of Tat-interacting protein of 110 kDa and microRNAs in the regulation of hematopoiesis.
Curr Opin Hematol. 2016 Jul;23(4):325-30. doi: 10.1097/MOH.0000000000000246.
7
HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110.
J Biol Chem. 2002 Jun 28;277(26):23854-63. doi: 10.1074/jbc.M200773200. Epub 2002 Apr 16.
8
Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15.
Int J Biochem Cell Biol. 2014 Sep;54:10-9. doi: 10.1016/j.biocel.2014.06.017. Epub 2014 Jun 28.
9
Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation.
J Biol Chem. 2004 May 21;279(21):21766-73. doi: 10.1074/jbc.M314321200. Epub 2004 Mar 18.
10
MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis.
Stem Cells Dev. 2015 Sep 1;24(17):2009-17. doi: 10.1089/scd.2015.0030. Epub 2015 May 11.
引用本文的文献
1
Interaction between RNF4 and SART3 is associated with the risk of schizophrenia.
Heliyon. 2024 Jun 8;10(12):e32743. doi: 10.1016/j.heliyon.2024.e32743. eCollection 2024 Jun 30.
2
SART3, regulated by p53, is a biomarker for diagnosis, prognosis and immune infiltration in hepatocellular carcinoma.
Aging (Albany NY). 2023 Aug 24;15(16):8408-8432. doi: 10.18632/aging.204978.
3
Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects.
Nat Commun. 2023 Jun 9;14(1):3403. doi: 10.1038/s41467-023-39040-0.
4
The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway.
Cell Death Dis. 2021 Oct 5;12(10):906. doi: 10.1038/s41419-021-04215-4.
5
The RNA-binding protein SART3 promotes miR-34a biogenesis and G cell cycle arrest in lung cancer cells.
J Biol Chem. 2019 Nov 15;294(46):17188-17196. doi: 10.1074/jbc.AC119.010419. Epub 2019 Oct 16.
6
miRNA regulation of Tip110 expression and self-renewal and differentiation of human CD34+ hematopoietic cells.
Oncotarget. 2017 Dec 21;9(4):4823-4832. doi: 10.18632/oncotarget.23572. eCollection 2018 Jan 12.
7
Stress granule-associated protein G3BP2 regulates breast tumor initiation.
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1033-1038. doi: 10.1073/pnas.1525387114. Epub 2017 Jan 17.
8
A functional genomics screen identifies an Importin-α homolog as a regulator of stem cell function and tissue patterning during planarian regeneration.
BMC Genomics. 2015 Oct 12;16:769. doi: 10.1186/s12864-015-1979-1.
9
Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing.
Cell Biosci. 2015 Jul 23;5:40. doi: 10.1186/s13578-015-0032-z. eCollection 2015.
10
Tip110 Regulates the Cross Talk between p53 and Hypoxia-Inducible Factor 1α under Hypoxia and Promotes Survival of Cancer Cells.
Mol Cell Biol. 2015 Jul;35(13):2254-64. doi: 10.1128/MCB.00001-15. Epub 2015 May 4.
本文引用的文献
1
TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC.
Blood. 2011 May 26;117(21):5643-51. doi: 10.1182/blood-2010-12-325332. Epub 2011 Mar 29.
2
Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood.
Blood. 2011 May 5;117(18):4773-7. doi: 10.1182/blood-2011-01-330514. Epub 2011 Mar 10.
3
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.
Nat Biotechnol. 2009 Nov;27(11):1033-7. doi: 10.1038/nbt.1580. Epub 2009 Oct 11.
4
OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells.
Stem Cells. 2008 Dec;26(12):3068-74. doi: 10.1634/stemcells.2008-0530. Epub 2008 Sep 11.
5
Nanog and transcriptional networks in embryonic stem cell pluripotency.
Cell Res. 2007 Jan;17(1):42-9. doi: 10.1038/sj.cr.7310125.
6
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
Nat Genet. 2006 Apr;38(4):431-40. doi: 10.1038/ng1760. Epub 2006 Mar 5.
7
Core transcriptional regulatory circuitry in human embryonic stem cells.
Cell. 2005 Sep 23;122(6):947-56. doi: 10.1016/j.cell.2005.08.020.
8
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells.
Mol Cell Biol. 2005 Jul;25(14):6031-46. doi: 10.1128/MCB.25.14.6031-6046.2005.
9
Self-renewal of teratocarcinoma and embryonic stem cells.
Oncogene. 2004 Sep 20;23(43):7150-60. doi: 10.1038/sj.onc.1207930.
10
Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells.
Stem Cells. 2004;22(5):659-68. doi: 10.1634/stemcells.22-5-659.
Zotero 插件