School of Clinical Sciences, Division of Ophthalmology and Visual Sciences, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
Ophthalmology. 2012 Mar;119(3):501-8. doi: 10.1016/j.ophtha.2011.08.024. Epub 2011 Nov 30.
To establish prospectively the normal values of corneal density of healthy subjects using the Pentacam Scheimpflug system (Oculus, Inc., Wetzlar, Germany) and to investigate alteration in corneal density during active and healed stages of bacterial keratitis.
Prospective, comparative case series.
Sixty-four eyes of 40 healthy controls and 36 eyes of 35 patients with bacterial keratitis were studied.
This study was conducted at the Queen's Medical Centre, Nottingham, United Kingdom. A Pentacam system was used to study corneal density. Corneal densitometry readings in subjects with bacterial keratitis were recorded during the active stage and 4 to 6 weeks after complete healing. Densitometry was recorded at the site of infection and at a point in clear cornea furthest away from the infectious infiltrate. Corneal thickness also was measured.
Densitometry values of normal cornea, at the site of corneal ulcer or abscess, and at a distant point of clear cornea during active and healed keratitis.
The mean densitometry value of normal corneas was 12.3 ± 2.4. In infectious keratitis, the densitometry values were greatest at the site of the active infection and significantly more than in controls. The densitometry values at the points of clear cornea furthest away from the site of infection also were significantly higher than in controls during active disease, but failed to return to normal values, despite complete resolution of infection. The density of the infiltrates was much higher than that of residual scars after healing of ulcers. No correlation was found between the pachymetry and the densitometry values.
Densitometry of active infectious corneal infiltrates is more than that resulting from the corneal scarring after healing. Persistent increase in density of clear cornea furthest away from the focus of corneal infection suggests that the host response extends beyond the immediate area of infection and indeed may occur through the entire cornea. These changes persist beyond 4 weeks of healing, which was the duration of follow-up of this study. Densitometry can be used as an objective measure of the corneal response to infection and to monitor response to therapy.
使用 Pentacam Scheimpflug 系统（德国 Oculus 公司）前瞻性地建立健康受试者的角膜密度正常值，并研究细菌性角膜炎活动期和愈合期角膜密度的变化。
前瞻性、比较病例系列。
40 名健康对照者的 64 只眼和 35 名细菌性角膜炎患者的 36 只眼纳入本研究。
该研究在英国诺丁汉的皇后医学中心进行。使用 Pentacam 系统研究角膜密度。在细菌性角膜炎患者的活动期以及完全愈合后 4 至 6 周记录角膜密度测量值。在感染部位和远离感染浸润的透明角膜的最远点记录密度测量值。还测量了角膜厚度。
正常角膜、角膜溃疡或脓肿部位以及活动性和愈合性角膜炎时远离感染部位的透明角膜的密度测量值。
正常角膜的平均密度值为 12.3±2.4。在感染性角膜炎中，密度值在活动性感染部位最大，明显高于对照组。在远离感染部位的透明角膜点，密度值在疾病活动期也明显高于对照组，但尽管感染已完全消退，仍未恢复正常。浸润的密度远高于溃疡愈合后的残余瘢痕。在愈合后，角膜厚度与密度值之间无相关性。
活动性感染性角膜浸润的密度高于愈合后角膜瘢痕的密度。远离感染灶的透明角膜密度持续增加提示宿主反应超出了感染的直接区域，实际上可能发生在整个角膜。这些变化持续超过愈合后的 4 周，这是本研究的随访时间。密度测量可作为角膜对感染的反应的客观指标，并可监测对治疗的反应。
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