Department of Medicine, University of Washington, Seattle, Washington, USA.
J Clin Invest. 2011 Dec;121(12):4600-9. doi: 10.1172/JCI57148. Epub 2011 Dec 1.
Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 vaccines have been studied in animal models, few have reached clinical trials, and those that have been tested in humans were not consistently effective. Here, we review HSV-2 pathogenesis, with a focus on novel understanding of mucosal immunobiology of HSV-2, and vaccine efforts to date, in an attempt to stimulate thinking about future directions for development of effective prophylactic and therapeutic HSV-2 vaccines.
单纯疱疹病毒 2 型(HSV-2)是全球最常见的性传播感染之一。除了复发性生殖器溃疡外,HSV-2 还会导致新生儿疱疹,并使 HIV 感染的风险增加 3 倍。尽管已经在动物模型中研究了许多 HSV-2 疫苗,但很少有疫苗进入临床试验,而且在人类中进行测试的疫苗也并非始终有效。在这里,我们回顾了 HSV-2 的发病机制,重点介绍了对 HSV-2 黏膜免疫生物学的新认识,以及迄今为止的疫苗研究进展,以期激发人们对开发有效预防和治疗 HSV-2 疫苗的未来方向的思考。