Kirby Emily J, Zhou Hong Holly, Morales Louis
Craniofacial Foundation of Utah, Salt Lake City, Utah 84117, USA.
J Craniofac Surg. 2011 Nov;22(6):2399-405. doi: 10.1097/SCS.0b013e318231fe9b.
A 16-year-old adolescent boy presented with osteosarcoma of the left parieto-occipital bone with no history of radiation, Paget disease, or retinoblastoma. The tumor presented as a painless lump, which he attributed to minor trauma 5 months before presentation. Biopsy of the lesion was inconclusive. Complete surgical resection was attained. Pathology revealed a diagnosis of osteosarcoma, grade 1 to 2/3. Adjuvant chemotherapy commenced after tumor resection. Primary pediatric osteosarcoma of the skull is an exceedingly rare malignancy, with only a handful of cases ever reported. Complete surgical resection with negative margins is the key to optimizing disease-free survival. Adjuvant chemotherapy is recommended for high-grade tumors and in cases of incomplete resection.
一名16岁青少年男性因左顶枕骨骨肉瘤就诊，无放疗、佩吉特病或视网膜母细胞瘤病史。肿瘤表现为无痛性肿块，他认为是就诊前5个月的轻微外伤所致。病变活检结果不明确。已完成手术完整切除。病理诊断为骨肉瘤，1至2/3级。肿瘤切除后开始辅助化疗。原发性小儿颅骨骨肉瘤是一种极其罕见的恶性肿瘤，仅有少数病例报道。切缘阴性的完整手术切除是优化无病生存期的关键。对于高级别肿瘤及切除不完全的病例，建议进行辅助化疗。
