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鼻腔软骨母细胞型骨肉瘤：一种罕见且易误诊的表现。

Chondroblastic osteosarcoma of the nasal cavity: an exceptional and misdiagnosed presentation.

作者信息

Aaboudech Taha Yassine, El Ouazzani Hafsa, Kadiri Habiba, Benabdenbi Hanae, Rguieg Naji, El Ouali Ibtissam, El Kettani N Ech-Cherif, Zouaidia Fouad, Cherradi Nadia

机构信息

Pathology Department, Rabat Specialty Hospital, Rabat 10100, Morocco.

Mohammed V University in Rabat, Rabat 10000, Morocco.

出版信息

J Surg Case Rep. 2024 Jun 6;2024(6):rjae409. doi: 10.1093/jscr/rjae409. eCollection 2024 Jun.

DOI:10.1093/jscr/rjae409
PMID:38845795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11155414/
Abstract

Chondroblastic osteosarcoma of the nasal cavity is a rare and aggressive tumor that presents diagnostic challenges due to its variable clinical and radiological features. Histological analysis is crucial for an accurate diagnosis, despite morphological similarities with chondrosarcoma. We present a case of primary craniofacial chondroblastic osteosarcoma originating from the nasal cavity in a 17-year-old adolescent. The tumor was characterized by cartilaginous lobules and spindle cell proliferation with osteoid matrix deposition. Immunohistochemical analysis supported the diagnosis. This case highlights the rarity of this particular presentation and emphasizes the significance of accurate diagnosis through histopathological evaluation to achieve optimal management.

摘要

鼻腔软骨母细胞型骨肉瘤是一种罕见且侵袭性强的肿瘤，因其临床和放射学特征多变而带来诊断挑战。尽管与软骨肉瘤在形态上有相似之处，但组织学分析对于准确诊断至关重要。我们报告一例17岁青少年原发于鼻腔的颅面部软骨母细胞型骨肉瘤病例。该肿瘤的特征为软骨小叶和梭形细胞增生，并伴有类骨质基质沉积。免疫组化分析支持该诊断。此病例凸显了这种特殊表现的罕见性，并强调了通过组织病理学评估进行准确诊断以实现最佳治疗的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d3/11155414/1ca8f75fda5a/rjae409f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d3/11155414/12a1954ed776/rjae409f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d3/11155414/7d682168e38f/rjae409f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d3/11155414/f6815f4e6976/rjae409f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d3/11155414/1ca8f75fda5a/rjae409f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d3/11155414/12a1954ed776/rjae409f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d3/11155414/7d682168e38f/rjae409f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d3/11155414/f6815f4e6976/rjae409f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8d3/11155414/1ca8f75fda5a/rjae409f4.jpg

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本文引用的文献

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Sinonasal Osteosarcoma: Report of 14 New Cases and Systematic Review of the Literature.鼻窦骨肉瘤：14例新病例报告及文献系统综述
J Neurol Surg B Skull Base. 2021 Jul;82(Suppl 3):e138-e147. doi: 10.1055/s-0040-1701221. Epub 2020 Jan 24.
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Chondroblastic osteosarcoma-A case report and review of literature.软骨母细胞性骨肉瘤——病例报告及文献综述
Clin Case Rep. 2019 Sep 30;8(11):2097-2102. doi: 10.1002/ccr3.1761. eCollection 2020 Nov.
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Gnathic osteosarcomas, experience of four institutions from Turkey.颌骨骨肉瘤：来自土耳其四个机构的经验
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Osteosarcoma: Diagnostic dilemmas in histopathology and prognostic factors.骨肉瘤：组织病理学中的诊断难题及预后因素
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Clin Exp Otorhinolaryngol. 2012 Dec;5(4):237-9. doi: 10.3342/ceo.2012.5.4.237. Epub 2011 Sep 15.
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J Craniofac Surg. 2011 Nov;22(6):2399-405. doi: 10.1097/SCS.0b013e318231fe9b.
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J Med Case Rep. 2009 Dec 11;3:9327. doi: 10.1186/1752-1947-3-9327.
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Skeletal Radiol. 2007 May;36(5):459-62. doi: 10.1007/s00256-006-0231-0. Epub 2006 Nov 8.
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Low-grade osteosarcoma of the maxillary sinus.上颌窦低度恶性骨肉瘤。
Skeletal Radiol. 2003 Mar;32(3):161-4. doi: 10.1007/s00256-002-0577-x. Epub 2002 Oct 19.
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Primary osteosarcoma of the head and neck in pediatric patients: a clinicopathologic study of 22 cases with a review of the literature.小儿头颈部原发性骨肉瘤：22例临床病理研究并文献复习
Cancer. 2001 Feb 1;91(3):598-605.