用于活体研究脑连接和可塑性的双重功能探针。
Dual-functional probes towards in vivo studies of brain connectivity and plasticity.
机构信息
Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Spemannstr. 38, 72076, Tübingen, Germany.
出版信息
Chem Commun (Camb). 2012 Mar 14;48(22):2755-7. doi: 10.1039/c1cc15991g. Epub 2011 Dec 1.
PMID:22134380
Abstract
A Gd(3+) based paramagnetic dextran conjugate has been developed, which enables the tracking of neuroanatomical connectivity in the brain by both MR and optical imaging. Cell studies and subsequent in vivo experiments in rodents demonstrate efficient internalisation and transport properties of the new tracer molecule.
摘要
一种基于 Gd(3+) 的顺磁葡聚糖偶联物已经被开发出来，它可以通过磁共振成像和光学成像来追踪大脑中的神经解剖连接。细胞研究和随后在啮齿动物体内的实验证明了这种新示踪剂分子具有高效的内化和转运特性。
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