基于 1,1'-双(氨基)二茂铁的大环 DTPA 轭合物的 Gd 配合物作为高弛豫率 MRI 血池对比剂 (BPCAs)。
Gd-complexes of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs).
机构信息
Department of Medical & Biological Engineering, Kyungpook National University, Daegu, 702-701, Korea.
出版信息
Chem Commun (Camb). 2010 Nov 28;46(44):8442-4. doi: 10.1039/c0cc03145c. Epub 2010 Oct 1.
PMID:20886175
Abstract
We report the synthesis of macrocyclic DTPA conjugates of 1,1'-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H(2)O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R(1) relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.
摘要
我们报告了 1,1'-双（氨基）二茂铁（1a-b）的大环 DTPA 缀合物及其 Gd 配合物[Gd（L）（H（2）O）]（2a-b，L=1a-b）的合成，可作为新型 MRI 血池造影剂。2a 在 HSA 中表现出高 R（1）弛豫率以及高热力学和动力学稳定性。
Zotero 插件