Goodman S R, Prezyna C, Clough W
IARC Sci Publ (1971). 1978(24 Pt 1):395-405.
Virally induced DNA polymerases have been demonstrated in cells infected with a variety of herpesviruses. These include herpes simplex virus (Weissbach et al., 1973), Marek's disease virus (Boezi et al., 1974), equine herpesvirus (Allen et al., 1977), and cytomegalovirus (Huang, 1975a). Recently a new iododeoxyuridine (IUDR)-induced intracellular DNA polymerase in an Epstein-Barr virus (EBV)-producing hybrid cell line has also been reported (Miller et al., 1977). We present evidence that there are two different DNA polymerase activities associated with EBV, one intracellular and the other virion-associated. Both of these enzymes have certain biochemical characteristics which distinguish them from each other, and from the host-cell DNA polymerases found in lymphocytes.
在感染多种疱疹病毒的细胞中已证实存在病毒诱导的DNA聚合酶。这些病毒包括单纯疱疹病毒（魏斯巴赫等人，1973年）、马立克氏病病毒（博齐等人，1974年）、马疱疹病毒（艾伦等人，1977年）和巨细胞病毒（黄，1975a）。最近，也有报道称在产生爱泼斯坦-巴尔病毒（EBV）的杂交细胞系中发现了一种新的碘脱氧尿苷（IUDR）诱导的细胞内DNA聚合酶（米勒等人，1977年）。我们提供的证据表明，与EBV相关的有两种不同的DNA聚合酶活性，一种是细胞内的，另一种与病毒粒子相关。这两种酶都具有某些生化特性，使它们彼此区分开来，也与淋巴细胞中发现的宿主细胞DNA聚合酶不同。
