Torres Tiago, Pinto Almeida Teresa, Alves Rosario, Sanches Madalena, Selores Manuela
Department of Dermatology, Hospital de Santo António, Porto, Portugal.
J Drugs Dermatol. 2011 Dec;10(12):1466-8.
Granuloma annulare is a benign, usually self-limited, dermatosis of unknown cause. Generalized lesions occur in approximately 15 percent of patients with GA and may cause mild to severe cosmetic disfigurement. The treatment of generalized granuloma annulare can be challenging. We report the case of a 36-year-old male patient with a generalized granuloma annulare who had failed topical and systemic glucocorticoids, systemic retinoids, dapsone, minocycline, PUVA therapy, and hydroxicloroquine and was successfully treated with adalimumab, an anti-TNF-α monoclonal antibody. Adalimumab may be an additional option in the treatment of recalcitrant forms of granuloma annulare.
环状肉芽肿是一种病因不明的良性、通常自限性的皮肤病。约15%的环状肉芽肿患者会出现全身性损害，可能导致轻至重度的容貌损毁。全身性环状肉芽肿的治疗颇具挑战性。我们报告一例36岁男性全身性环状肉芽肿患者，其局部及全身性糖皮质激素、全身性维甲酸、氨苯砜、米诺环素、光化学疗法（PUVA）及羟氯喹治疗均无效，而使用抗TNF-α单克隆抗体阿达木单抗成功治愈。阿达木单抗可能是治疗顽固性环状肉芽肿的一种额外选择。
