糖尿病：将糖化血红蛋白（HbA₁c）标准化至最高计量级水平的漫长之路。
Diabetes mellitus: the long way of standardization of HbA(1c) to the level of highest metrological order.
作者信息
Kaiser Patricia, Reinauer Hans
机构信息
Instand e.V., Düsseldorf, Germany.
出版信息
Ger Med Sci. 2011;9:Doc28. doi: 10.3205/000151. Epub 2011 Nov 9.
Abstract
Glycated haemoglobin (HbA(1c)) measurements are used in clinical studies and for the management of diabetic patients. Various efforts were made to standardize the HbA(1c) measurements with consensus standards and standards based on a reference measurement procedure with external calibration. According to ISO 17511 a standard should meet highest accuracy possible, have a defined uncertainty of measurement and the calibration should be traceable to SI units. For HbA(1c) this has been realized using a LC-ID-MS procedure based on the existing reference measurement procedure.
摘要
糖化血红蛋白（HbA(1c)）测量用于临床研究及糖尿病患者的管理。人们做出了各种努力，以基于共识标准和基于外部校准的参考测量程序的标准来规范HbA(1c)测量。根据ISO 17511，一项标准应尽可能达到最高准确度，具有规定的测量不确定度，且校准应可溯源至国际单位制（SI）单位。对于HbA(1c)，这已通过基于现有参考测量程序的液相色谱-同位素稀释-质谱（LC-ID-MS）程序得以实现。
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