Sabalesky D A, Demet E M, Chicz-Demet A, Gottschalk L A, Haier R J
Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine 92717.
J Psychiatr Res. 1990;24(2):165-75. doi: 10.1016/0022-3956(90)90056-v.
Platelet MAO activity has been reported by several investigators to differentiate schizophrenia, schizophrenia related depressive disorders, alcoholism, unipolar and bipolar depression from normal controls. Evoked potentials likewise have differentiated schizophrenic and affective patients. However, the precise relationship between MAO activity, evoked potentials (EP), and psychiatric illness has not been clarified. A possible association between psychopathology and high MAO activity/EP reducing and low MAO activity/EP augmenting has been reported. Such a bidirectionality further confounds results. This study was undertaken to determine the association of psychopathological dimensions found in a group of subjects whose platelet MAO activity and evoked responses were obtained two years earlier. Utilizing the Gottschalk-Gleser verbal behavior scales of Anxiety, Depression, Social Alienation-Personal Disorganization and Cognitive Impairment a significant correlation was revealed between low platelet MAO activity and high Total Anxiety scale and Shame Anxiety subscale scores. Additionally, a significant correlation was demonstrated between reducing evoked potentials and elevated Death Anxiety, Somatic Concerns, and Total Death and Mutilation Depression subscales scores, combined and separately. Furthermore, a significant positive correlation was found between augmenting evoked potentials and Overt Hostility Outward scores. No significant correlations were demonstrated between platelet MAO activity or evoked potentials and Social Alienation-Personal Disorganization or Cognitive Impairment scores. These findings lend support to the position that biological markers may predict predispositions to anxiety and depression.
几位研究者报告称，血小板单胺氧化酶（MAO）活性可用于区分精神分裂症、与精神分裂症相关的抑郁障碍、酒精中毒、单相和双相抑郁症与正常对照组。诱发电位同样也能区分精神分裂症患者和情感障碍患者。然而，MAO活性、诱发电位（EP）与精神疾病之间的确切关系尚未阐明。有报告称，精神病理学与高MAO活性/EP降低以及低MAO活性/EP增强之间可能存在关联。这种双向性进一步混淆了研究结果。本研究旨在确定一组两年前已获得血小板MAO活性和诱发反应的受试者中所发现的精神病理学维度之间的关联。利用戈特沙尔克 - 格勒泽言语行为焦虑量表、抑郁量表、社会疏离 - 个人紊乱量表和认知障碍量表，发现血小板MAO活性低与总焦虑量表及羞耻焦虑子量表得分高之间存在显著相关性。此外，诱发反应降低与死亡焦虑、躯体担忧以及总死亡和毁伤抑郁子量表得分升高之间，无论合并还是单独分析，均显示出显著相关性。此外，诱发反应增强与明显外向敌意得分之间存在显著正相关。血小板MAO活性或诱发电位与社会疏离 - 个人紊乱或认知障碍量表得分之间未显示出显著相关性。这些发现支持了生物标志物可能预测焦虑和抑郁易感性这一观点。
