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抑郁症的生物学易感性:单胺氧化酶和诱发电位作为危险因素的复制研究

Biological vulnerability to depression: replication of MAO and evoked potentials as risk factors.

作者信息

Haier R J, Buchsbaum M S, DeMet E, Wu J

机构信息

Department of Psychiatry, University of California, Irvine.

出版信息

Neuropsychobiology. 1988;20(2):62-6. doi: 10.1159/000118474.

DOI:10.1159/000118474
PMID:3253603
Abstract

In previous work, we have reported that specific combinations of platelet (MAO) activity and evoked potential augmenting/reducing (AR) are associated with risk for affective disorders. This new study screened 271 college freshmen solely on MAO and AR and selected a sample with extreme values on both measures. These students were interviewed with the Diagnostic Interview Schedule and they completed a family history questionnaire and psychosocial scales. Following the previous work, the same MAO and AR combinations were related to the frequency of major depression and a family history of psychiatric disorder.

摘要

在之前的研究中,我们曾报道血小板(MAO)活性与诱发电位增强/减弱(AR)的特定组合与情感障碍风险相关。这项新研究仅根据MAO和AR对271名大学新生进行筛选,并选取了在这两项指标上都处于极端值的样本。这些学生接受了《诊断访谈表》的访谈,并完成了一份家族史问卷和社会心理量表。与之前的研究一致,相同的MAO和AR组合与重度抑郁症的发病频率以及精神疾病家族史有关。

相似文献

1
Biological vulnerability to depression: replication of MAO and evoked potentials as risk factors.抑郁症的生物学易感性:单胺氧化酶和诱发电位作为危险因素的复制研究
Neuropsychobiology. 1988;20(2):62-6. doi: 10.1159/000118474.
2
Platelet monoamine oxidase activity and evoked response as predictors of anxiety and depression derived from the content analysis of speech.血小板单胺氧化酶活性和诱发反应作为从言语内容分析得出的焦虑和抑郁预测指标。
J Psychiatr Res. 1990;24(2):165-75. doi: 10.1016/0022-3956(90)90056-v.
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An 18-month followup of students biologically at risk for psychiatric problems.对在生物学上有精神问题风险的学生进行的18个月随访。
Schizophr Bull. 1980;6(2):334-7. doi: 10.1093/schbul/6.2.334.
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Platelet MAO activity and evoked potentials in the identification of subjects biologically at risk for psychiatric disorders.血小板单胺氧化酶活性与诱发电位在识别有患精神疾病生物学风险的受试者中的应用
Br J Psychiatry. 1979 Apr;134:372-81. doi: 10.1192/bjp.134.4.372.
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Psychiatric vulnerability, monoamine oxidase, and the average evoked potential.精神易损性、单胺氧化酶与平均诱发电位。
Arch Gen Psychiatry. 1980 Mar;37(3):340-5. doi: 10.1001/archpsyc.1980.01780160110013.
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Suicide attempts, platelet monoamine oxidase and the average evoked response.自杀未遂、血小板单胺氧化酶与平均诱发电位
Acta Psychiatr Scand. 1977 Jul;56(1):69-79. doi: 10.1111/j.1600-0447.1977.tb06665.x.
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Toward a biochemical classification of depressive disorders, VI: Platelet MAO activity and clinical symptoms in depressed patients.
Am J Psychiatry. 1982 May;139(5):630-3. doi: 10.1176/ajp.139.5.630.
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Psychological characteristics of subjects identified by platelet MAO activity and evoked potentials as biologically at risk for psychopathology.通过血小板单胺氧化酶活性和诱发电位确定为具有精神病理学生物学风险的受试者的心理特征。
J Abnorm Psychol. 1980 Apr;89(2):151-64. doi: 10.1037//0021-843x.89.2.151.
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Relationship of platelet MAO activity to characteristics of major depressive illness.血小板单胺氧化酶活性与重度抑郁症特征的关系。
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The biochemical high-risk paradigm: behavioral and familial correlates of low platelet monoamine oxidase activity.生化高危范式:低血小板单胺氧化酶活性的行为及家族相关性
Science. 1976 Oct 15;194(4262):339-41. doi: 10.1126/science.968488.

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