De Santi S, de Leon M J, Convit A, Tarshish C, Rusinek H, Tsui W H, Sinaiko E, Wang G J, Bartlet E, Volkow N
Aging and Dementia Research Center, New York University Medical Center,NY 10016, USA.
Psychiatr Q. 1995 Winter;66(4):357-70. doi: 10.1007/BF02238755.
While many neuropsychological studies have demonstrated age-related performance alterations in tests thought to reflect frontal and temporal lobe function, there is little direct observation and comparison of these hypothesized brain changes in vivo. The cerebral glucose metabolism of frontal, temporal, and cerebellar regions was examined in 40 young (mean = 27.5 +/- 4.9) and 31 elderly (mean = 67.6 +/- 8.8) normal males using PET-FDG. Univariate analysis showed age-related metabolic reductions in all frontal and temporal lobe regions. The reductions ranged from 13%-24% with the greatest changes in the frontal lobes. Multiple regression analyses showed a stronger age relationship with frontal lobe than with temporal lobe metabolism. The dorsal lateral frontal lobe was the region that appears to change most within the frontal lobes. Examination of the temporal lobe showed that age contributed equally to the metabolic variance of both the lateral temporal lobe and hippocampus. These results suggest that age-related metabolic changes exist in both frontal and temporal lobes and that the frontal lobe change is greater.
虽然许多神经心理学研究已证明，在被认为反映额叶和颞叶功能的测试中，存在与年龄相关的表现变化，但在活体中对这些假定的大脑变化进行的直接观察和比较却很少。使用正电子发射断层显像 - 氟代脱氧葡萄糖（PET-FDG）对40名年轻（平均年龄 = 27.5 ± 4.9）和31名老年（平均年龄 = 67.6 ± 8.8）正常男性的额叶、颞叶和小脑区域的脑葡萄糖代谢进行了检查。单因素分析显示，所有额叶和颞叶区域均存在与年龄相关的代谢降低。降低幅度在13% - 24%之间，额叶变化最大。多元回归分析显示，与颞叶代谢相比，年龄与额叶代谢的关系更强。背外侧额叶是额叶内变化最明显的区域。对颞叶的检查表明，年龄对颞叶外侧和海马体的代谢差异贡献相同。这些结果表明，额叶和颞叶均存在与年龄相关的代谢变化，且额叶变化更大。
