REM 行为障碍与神经退行性疾病。
REM behaviour disorder and neurodegenerative diseases.
机构信息
Clinica Neurologica, Department of Neurological Sciences, University of Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy.
出版信息
Sleep Med. 2011 Dec;12 Suppl 2:S54-8. doi: 10.1016/j.sleep.2011.10.012.
Rapid-eye movement (REM) sleep behaviour disorder (RBD) is an REM sleep parasomnia characterized by enactment of dream content during REM sleep associated with loss of muscle atonia. RBD can be either idiopathic or secondary to drugs or other diseases. The best recognized association is with neurodegenerative diseases, namely alpha-synucleinopathies. RBD may represent the first feature of neurodegeneration and can be considered an early marker of these disorders. This review describes the main clinical, pathogenetic, and therapeutic features of RBD, pointing to its association with neurodegenerative diseases and emphasizing the clinical and prognostic implications.
快速眼动（REM）睡眠行为障碍（RBD）是一种 REM 睡眠异态，其特征是在 REM 睡眠期间表现出梦境内容，同时伴有肌肉弛缓丧失。RBD 可以是特发性的，也可以是由药物或其他疾病引起的。最被认可的关联是与神经退行性疾病，即α-突触核蛋白病。RBD 可能代表神经退行性变的第一个特征，并且可以被认为是这些疾病的早期标志物。本文综述了 RBD 的主要临床、发病机制和治疗特征，指出其与神经退行性疾病的关联，并强调了其临床和预后意义。
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