Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts 02129, USA.
J Am Coll Radiol. 2011 Dec;8(12):848-52. doi: 10.1016/j.jacr.2011.08.009.
Concern regarding incidental findings on brain MRI studies has been increasing with the growing use of MRI as tool for scientific investigation. In this article, the authors provide an overview of possible approaches to address incidental findings. Incidental findings are surprisingly common (5%-20% of all examinations), although the percentage of clinically serious abnormalities is low (0.3%-3.4%). At present, there is no consensus concerning the optimal strategy on how to deal with incidental findings, in particular how to fulfill ethical responsibilities appropriately within the constraints of available resources. There are a variety of responses possible, and currently, reasonable guidelines exist for formulating a plan tailored to the needs of each institution that will meet the reasonable expectations of subjects participating in brain research studies.
随着 MRI 在科学研究中的应用越来越广泛，人们对脑 MRI 研究中偶然发现的关注也在不断增加。本文作者提供了一种可能的方法来处理偶然发现的问题。偶然发现非常常见（所有检查的 5%-20%），尽管临床上严重异常的比例较低（0.3%-3.4%）。目前，对于如何处理偶然发现的问题，特别是如何在现有资源的限制下适当地履行伦理责任，尚未达成共识。有多种可能的应对方式，目前，对于制定符合每个机构需求的计划以及满足参与脑研究的受试者的合理期望，已经存在合理的指导方针。
