Montefiore Medical Center, Albert Einstein College of Medicine, Department of Psychiatry and Behavioral Sciences, 111 E 210th Street, Bronx, NY 10467, USA.
Neurosci Biobehav Rev. 2012 Feb;36(2):960-8. doi: 10.1016/j.neubiorev.2011.11.005. Epub 2011 Nov 28.
Psychosis in schizophrenia is associated with source-monitoring deficits whereby self-initiated behaviors become attributed to outside sources. One of the proposed functions of the thalamus is to adjust sensory responsiveness in accordance with the behavioral contextual cues. The thalamus is markedly affected in schizophrenia, and thalamic dysfunction may here result in reduced ability to adjust sensory responsiveness to ongoing behavior. One of the ways in which the thalamus accomplishes the adjustment of sensory processing is by a neurophysiological shift to post-inhibitory burst firing mode prior to and during certain exploratory actions. Reduced amount of thalamic burst firing may result from increased neuronal excitability secondary to a reported potassium channel dysfunction in schizophrenia. Pharmacological agents that reduce the excitability of thalamic cells and thereby promote burst firing by and large tend to have antipsychotic effects.
精神分裂症中的精神病与来源监测缺陷有关，即自我启动的行为被归因于外部来源。丘脑的一个拟议功能是根据行为上下文线索调整感觉反应。精神分裂症中丘脑明显受到影响，丘脑功能障碍可能导致对正在进行的行为的感觉反应调节能力降低。丘脑完成感觉处理调节的一种方式是在某些探索性动作之前和期间通过神经生理向抑制后爆发式发射模式转变。由于报道的精神分裂症钾通道功能障碍导致神经元兴奋性增加，可能导致丘脑爆发式发射减少。通过降低丘脑细胞兴奋性从而促进爆发式发射的药物通常具有抗精神病作用。
