钙结合蛋白 parvalbumin 如何在纳米域偶联状态下影响递质释放。
How the 'slow' Ca(2+) buffer parvalbumin affects transmitter release in nanodomain-coupling regimes.
机构信息
Physiological Institute I, University of Freiburg, Freiburg, Germany.
出版信息
Nat Neurosci. 2011 Dec 4;15(1):20-2. doi: 10.1038/nn.3002.
Abstract
Parvalbumin is thought to act in a manner similar to EGTA, but how a slow Ca(2+) buffer affects nanodomain-coupling regimes at GABAergic synapses is unclear. Direct measurements of parvalbumin concentration and paired recordings in rodent hippocampus and cerebellum revealed that parvalbumin affects synaptic dynamics only when expressed at high levels. Modeling suggests that, in high concentrations, parvalbumin may exert BAPTA-like effects, modulating nanodomain coupling via competition with local saturation of endogenous fixed buffers.
摘要
钙结合蛋白 parvalbumin 被认为作用方式类似于 EGTA，但不清楚缓慢的 Ca2+ 缓冲如何影响 GABA 能突触的纳米域偶联状态。在啮齿动物海马体和小脑的直接浓度测量和配对记录显示，只有在高水平表达时，钙结合蛋白 parvalbumin 才会影响突触动力学。模型表明，在高浓度下，钙结合蛋白 parvalbumin 可能发挥类似 BAPTA 的作用，通过与内源性固定缓冲剂的局部饱和竞争来调节纳米域偶联。
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