Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Cancer Immunol Immunother. 2012 Sep;61(9):1585-90. doi: 10.1007/s00262-011-1170-8. Epub 2011 Dec 3.
The nexus of chemotherapeutic intervention and the immunomodulation of IgE-related phenomena are not well understood. The relationship bears importance in better understanding the causal and/or resultant effects of one on the other and their collective role in the management and sequelae of the cancer patient. This review discusses the relationship of chemotherapy on immunoglobulins with a focus on IgE and other related biological processes including hypersensitivity reactions and proposes models toward effective management of the cancer patient in this regard.
化疗干预与 IgE 相关现象的免疫调节之间的关系尚不清楚。这种关系对于更好地理解彼此的因果关系或结果关系以及它们在癌症患者的管理和后果中的共同作用具有重要意义。本文讨论了化疗对免疫球蛋白的影响，重点是 IgE 及其他相关的生物学过程，包括过敏反应，并提出了在这方面有效管理癌症患者的模型。
