College of Pharmacy, Dongguk University-Seoul, Seoul 100-715, Korea.
Arch Pharm Res. 2011 Nov;34(11):1843-63. doi: 10.1007/s12272-011-1106-z. Epub 2011 Dec 3.
As the uses of herbal medicines from traditional natural products are increased, the need for pharmacokinetic studies and relevant data are also increased for safe pharmacotherapy. The market entry for the traditional herbal medicine is easier compared with that for synthetic drugs because of a lower regulatory barrier. Thus, the exact mechanisms for the absorption, distribution, metabolism and excretion of active components in herbal medicines and the potential herb-drug interactions are not always fully understood. Recently, there has been an increasing interest in pharmacokinetic studies of herbal remedies and relevant data of commonly used herbal remedies are accumulating in this field. In this review, the effects of nine botanicals (ginkgo, green tea, grapes, licorice, saw palmetto, garlic milk thistle, ginseng and St. John's wort) on metabolic enzymes and transporters affecting absorption and disposition of herbal products are summarized. The source of samples (extracts and individual components), the species (human and animal) and in vivo and in vitro systems were separately reviewed for a better understanding of herb-drug interactions.
随着从传统天然产物中使用草药的增加，安全药物治疗也需要进行药代动力学研究和相关数据。与合成药物相比，传统草药进入市场的门槛较低，因为监管障碍较低。因此，草药中活性成分的吸收、分布、代谢和排泄的具体机制以及潜在的草药-药物相互作用并不总是完全清楚。最近，人们对草药治疗的药代动力学研究越来越感兴趣，该领域中常用草药的相关数据也在不断积累。在这篇综述中，总结了 9 种植物（银杏、绿茶、葡萄、甘草、锯棕榈、大蒜、奶蓟草、人参和贯叶连翘）对影响草药产品吸收和处置的代谢酶和转运体的影响。为了更好地理解草药-药物相互作用，分别从样品来源（提取物和单一成分）、物种（人类和动物）以及体内和体外系统对其进行了综述。
