Lemon S M, Hutt L M, Shaw J E, Li J L, Pagano J S
IARC Sci Publ (1971). 1978(24 Pt 2):739-44.
Epstein-Barr virus (EBV)-specific complementary RNA (cRNA) was hybridized in situ to oropharyngeal epithelial cells taken from patients with infectious mononucleosis. Cells from patients shedding virus in the throat hybridized signifnicant quantities of cRNA, whereas cells from EBV-negative sources did not. The degree of hybridization indicated a large EBV genome number per infected epithelial cell and suggested that these cells were the source of virus found in the throat. This finding may explain the presence of the EBV genome in the malignant epithelial cells of nasopharyngeal carcinoma.
爱泼斯坦-巴尔病毒（EBV）特异性互补RNA（cRNA）原位杂交至传染性单核细胞增多症患者的口咽上皮细胞。咽喉部排出病毒的患者的细胞杂交出大量cRNA，而来自EBV阴性来源的细胞则没有。杂交程度表明每个受感染的上皮细胞中有大量EBV基因组，提示这些细胞是咽喉部发现的病毒来源。这一发现可能解释了鼻咽癌恶性上皮细胞中EBV基因组的存在。
