Department of Psychiatry, Columbia University and The New York State Psychiatric Institute, New York, NY 10032, USA.
Nucleic Acids Res. 2012 Jan;40(Database issue):D1245-9. doi: 10.1093/nar/gkr1193. Epub 2011 Dec 2.
MethylomeDB (http://epigenomics.columbia.edu/methylomedb/index.html) is a new database containing genome-wide brain DNA methylation profiles. DNA methylation is an important epigenetic mark in the mammalian brain. In human studies, aberrant DNA methylation alterations have been associated with various neurodevelopmental and neuropsychiatric disorders such as schizophrenia, and depression. In this database, we present methylation profiles of carefully selected non-psychiatric control, schizophrenia, and depression samples. We also include data on one mouse forebrain sample specimen to allow for cross-species comparisons. In addition to our DNA methylation data generated in-house, we have and will continue to include published DNA methylation data from other research groups with the focus on brain development and function. Users can view the methylation data at single-CpG resolution with the option of wiggle and microarray formats. They can also download methylation data for individual samples. MethylomeDB offers an important resource for research into brain function and behavior. It provides the first source of comprehensive brain methylome data, encompassing whole-genome DNA methylation profiles of human and mouse brain specimens that facilitate cross-species comparative epigenomic investigations, as well as investigations of schizophrenia and depression methylomes.
MethylomeDB（http://epigenomics.columbia.edu/methylomedb/index.html）是一个新的数据库，包含全基因组大脑 DNA 甲基化图谱。DNA 甲基化是哺乳动物大脑中的一种重要的表观遗传标记。在人类研究中，异常的 DNA 甲基化改变与各种神经发育和神经精神疾病有关，如精神分裂症和抑郁症。在这个数据库中，我们展示了精心挑选的非精神病对照、精神分裂症和抑郁症样本的甲基化图谱。我们还包括一个小鼠前脑样本的数据，以允许进行跨物种比较。除了我们内部生成的 DNA 甲基化数据外，我们还包括并将继续包括来自其他研究小组的已发表的 DNA 甲基化数据，重点是大脑发育和功能。用户可以以单个 CpG 的分辨率查看甲基化数据，并提供 wiggle 和微阵列格式的选项。他们还可以下载单个样本的甲基化数据。MethylomeDB 为研究大脑功能和行为提供了一个重要的资源。它提供了全面的大脑甲基组数据的第一个来源，包括人类和小鼠大脑标本的全基因组 DNA 甲基化图谱，促进了跨物种的比较表观基因组学研究，以及精神分裂症和抑郁症甲基组学的研究。
