Miller R L, Iltis J P, Rapp F
IARC Sci Publ (1971). 1978(24 Pt 2):991-7.
The thymidine analogue, 1-beta-arabinofuranosylthymine (ara-T), has previously been found to selectively inhibit herpes simplex virus (HSV) replication. At a relatively non-toxic concentration (50 microgram/ml), ara-T reduced HSV yields by a factor of 10,000-100,000. Ara-T was also effective in inhibiting the replication of variecella-zoster virus (VZV) in vitro in human embryo fibroblasts, completely preventing VZV-specific cytopathic effects (CPE). Ara-T reduced the cell-free virus and plaque-forming cell (PFC) yields of VZV as well as of the simian varicella-like virus, Delta herpesvirus. In contrast to HSV and VZV, cytomegalovirus (CMV) replication was relatively resistant to ara-T. Neither CPE nor the incorporation of 3H-thymidine into acid-insoluble material in CMV-infected cells was markedly affected. Interpretation of these results with regard to virus-induced deoxypyrimidine kinase is discussed.
胸苷类似物1-β-D-阿拉伯呋喃糖基胸腺嘧啶（ara-T）先前已被发现可选择性抑制单纯疱疹病毒（HSV）复制。在相对无毒的浓度（50微克/毫升）下，ara-T可使HSV产量降低10000至100000倍。ara-T在体外人胚成纤维细胞中也能有效抑制水痘带状疱疹病毒（VZV）复制，完全防止VZV特异性细胞病变效应（CPE）。ara-T降低了VZV以及猴水痘样病毒（Delta疱疹病毒）的游离病毒和蚀斑形成细胞（PFC）产量。与HSV和VZV不同，巨细胞病毒（CMV）复制对ara-T相对耐药。CMV感染细胞中的CPE以及3H-胸腺嘧啶掺入酸不溶性物质均未受到明显影响。本文讨论了关于病毒诱导的脱氧嘧啶激酶对这些结果的解释。
