Shiraki K, Miyaki C, Namazue J, Yamanishi K, Takahashi M
Department of Virology, Osaka University, Japan.
Acta Virol. 1989 Dec;33(6):565-8.
Acyclovir (9-/2-hydroxyethoxymethyl/guanine) enhanced the plaque formation of HSV and VZV at subinhibitory dose and inhibited at higher concentration but not in thymidine kinase deficient viruses. The enhancement was neutralized by thymidine. Induction of viral thymidine kinase activity was not affected with ACV. These results suggest that the enhancement may be mediated by viral thymidine kinase.
阿昔洛韦（9 - /2 - 羟乙氧甲基/鸟嘌呤）在亚抑制剂量下可增强单纯疱疹病毒（HSV）和水痘 - 带状疱疹病毒（VZV）的蚀斑形成，在较高浓度时则起抑制作用，但对胸苷激酶缺陷型病毒无此作用。这种增强作用可被胸苷中和。阿昔洛韦对病毒胸苷激酶活性的诱导没有影响。这些结果表明，这种增强作用可能是由病毒胸苷激酶介导的。
