1-β-D-阿拉伯呋喃糖基胸腺嘧啶对1型和2型单纯疱疹病毒生长的影响。
The effect of 1-beta-D-arabinofuranosylthymine on the growth of herpes simplex virus types 1 and 2.
作者信息
Falke D, Moser H, Link D, Müller W E
出版信息
J Gen Virol. 1979 Feb;42(2):435-8. doi: 10.1099/0022-1317-42-2-435.
The influence of araT on the synthesis of HSV of types 1 and 2 including a TK(--) variant, on the activity of the dThd and the dCyd kinases and on the incorporation of radioactivity into insoluble or soluble material after infection was studied. AraT inhibited different parameters of the replication of a TK(--) variant; it is possibly phosphorylated by enzymes other than the deoxypyrimidine kinase and therefore it is less selectively phosphorylated than dThd. The mode of action of araT on herpes replication must be studied in more detail.
研究了阿糖胸苷（araT）对1型和2型单纯疱疹病毒（包括胸苷激酶缺陷型变异株）合成、脱氧胸苷激酶（dThd激酶）和脱氧胞苷激酶（dCyd激酶）活性以及感染后放射性掺入不溶性或可溶性物质的影响。阿糖胸苷抑制胸苷激酶缺陷型变异株复制的不同参数；它可能被脱氧嘧啶激酶以外的酶磷酸化，因此其磷酸化的选择性低于脱氧胸苷。必须更详细地研究阿糖胸苷对疱疹病毒复制的作用方式。
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