Departamento de Farmacia, Facultad de Química, UNAM, Mexico.
Expert Rev Clin Pharmacol. 2012 Jan;5(1):21-30. doi: 10.1586/ecp.11.72.
Human neurocysticercosis is a severe disease caused by the installation of Taenia solium larvae in the CNS. A wide variety of clinical manifestations are related to neurocysticercosis. These are determined by a number of important factors, including the number and location of the cysts, the stage of cystercerci and the host response to the infection. Epilepsy, focal neurological signs and increased intracranial pressure are the most common clinical manifestations of the disease. Neurocysticercosis is still deeply rooted in Latin America, Africa and Asia. Albendazole and praziquantel are the drugs used in the treatment of cysticercosis. Both drugs have limited solubility and extensive metabolism, and thus great interindividual variability in plasma levels is found. This article focuses on current knowledge of the pharmacokinetics and the drug interactions of the anthelmintic drugs and the perspectives in the treatment of this parasitic disease.
人体猪囊尾蚴病是由猪带绦虫幼虫在中枢神经系统中定植引起的严重疾病。多种临床表现与囊虫病有关。这些临床表现由多个重要因素决定，包括囊虫的数量和位置、囊尾蚴的阶段以及宿主对感染的反应。癫痫、局灶性神经体征和颅内压增高是该病最常见的临床表现。囊虫病在拉丁美洲、非洲和亚洲仍然根深蒂固。阿苯达唑和吡喹酮是治疗囊虫病的药物。这两种药物的溶解度有限，代谢广泛，因此在血浆水平中发现了很大的个体间变异性。本文重点介绍了抗蠕虫药物的药代动力学和药物相互作用的最新知识，以及治疗这种寄生虫病的前景。
