Mancino D, Bevilacqua N
Int Arch Allergy Appl Immunol. 1979;59(4):427-31. doi: 10.1159/000232290.
The effects of amorphous silica (Aerosil) and of aluminium hydroxide on anti-DNP IgE antibody production were studied in Swiss mice preimmunized with Ascaris protein and then challenged 7 days later with DNP-ASC. Aerosil exerted an adjuvant effect especially when it was injected together with the DNP-ASC conjugate. Al(OH)3 had a weaker adjuvant effect than that produced by Aerosil and then only when it was injected with the DNP-ASC conjugate. Al(OH)3 given with Ascaris extract 7 days before complete antigen had an inhibitory effect on the anti-DNP IgE antibody production.
研究了无定形二氧化硅（气相二氧化硅）和氢氧化铝对用蛔虫蛋白预先免疫，然后在7天后用二硝基苯基-抗链球菌溶血素C（DNP-ASC）攻击的瑞士小鼠抗DNP IgE抗体产生的影响。气相二氧化硅发挥了佐剂作用，特别是当它与DNP-ASC缀合物一起注射时。氢氧化铝的佐剂作用比气相二氧化硅产生的作用弱，并且只有当它与DNP-ASC缀合物一起注射时才具有佐剂作用。在完全抗原前7天与蛔虫提取物一起给予的氢氧化铝对抗DNP IgE抗体产生具有抑制作用。
