Yoneda T, Yoshikawa M, Tsukaguchi K, Egawa S, Morikawa A, Kasuga H, Narita N, Enoki Y, Mikami R
Second Department of Internal Medicine, Nara Medical University, Kashihara-shi.
Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Mar;28(3):465-72.
We assessed nutritional status in 30 patients with pulmonary emphysema and 60 healthy controls. The relationship between nutritional status, pulmonary function and respiratory muscle function was also studied. Anthropometric measures, visceral proteins such as PA and RPB, and the Fischer ratio (BCAA/AAA), an index of imbalance of amino acids were significantly lower in the patients. The incidence of moderately malnourished patients with less than 80% of IBW was 40%. The incidence of hyporetinol-binding protein was 40%. 48% of the patients were found to show an amino acid imbalance. These findings suggested that protein-energy malnutrition in association with amino acid imbalance occurred commonly in patients with pulmonary emphysema. FEV1% correlated significantly with some anthropometric indices and the Fischer ratio. Respiratory muscle function, assessed by P1 max, correlated significantly with some anthropometric indices and grasp strength. These results suggested that the degree of airway obstruction and respiratory muscle function was associated with malnutrition characterized by the reduction of the Fischer ratio.
我们评估了30例肺气肿患者和60名健康对照者的营养状况。还研究了营养状况、肺功能和呼吸肌功能之间的关系。患者的人体测量指标、诸如前白蛋白（PA）和视黄醇结合蛋白（RPB）等内脏蛋白以及作为氨基酸失衡指标的费舍尔比率（支链氨基酸/芳香族氨基酸）均显著降低。体重低于理想体重（IBW）80%的中度营养不良患者的发生率为40%。低视黄醇结合蛋白的发生率为40%。发现48%的患者存在氨基酸失衡。这些发现提示，蛋白质 - 能量营养不良伴氨基酸失衡在肺气肿患者中普遍存在。第1秒用力呼气容积百分比（FEV1%）与一些人体测量指标和费舍尔比率显著相关。通过最大吸气压（P1 max）评估的呼吸肌功能与一些人体测量指标和握力显著相关。这些结果提示，气道阻塞程度和呼吸肌功能与以费舍尔比率降低为特征的营养不良有关。
