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双相情感障碍中自知力与临床特征的关系。

The relationship between insight and clinical features in bipolar disorder.

作者信息

Güçlü Oya, Karaca Orhan, Yıldırım Bülent, Ozköse Mehmet Mustafa, Erkıran Murat

机构信息

Bakırköy Prof. Mazhar Osman Psychiatric and Neurological Illnesss Training and Investigation Hospital, 9th Psychiatry Clinic, İstanbul.

出版信息

Turk Psikiyatri Derg. 2011 Winter;22(4):230-8.

Abstract

OBJECTIVE

The aim of this study is to examine the relationship between insight dimensions and clinical features in bipolar disorder.

METHOD

One hundred and four inpatients with bipolar disorder( manic or mixed episodes) diagnosed according to DSM-IV criteria participated in the study. Patients were evaluated both during an acute episode and in remission, prior their discharge from the hospital by the Young Mania Rating Scale (YMRS), Montgomery-Asberg Depression Rating Scale (MADRS), Positive and Negative Syndrome Scale (PANSS), The Scale of Unawareness of Mental Disorders (SUMD), and a questionnaire regarding demographic and clinical characteristics.

RESULTS

In remission, 57 patients (54.8%) had insight of their illness while 14 (13.5%)did not have insight. Besides %6.7 of patients did not have the Insight into the effects of medication. We also found that 27.9% of patients were unaware of the social consequences of their illness. Patients with psychotic symptoms had a significantly low level of awareness to the effects of their medication as well as the severeness of their manic episode. We found an unawareness of delusion in these patients. In terms of all SUMD items, female patients had significantly poorer insight compared to men. No correlation was found between the number of hospitalizations, the number of episodes or the first episode type and insight dimensions.

CONCLUSION

Lack of insight in bipolar disorder is not rare. The assesment of insight addresses different components of the illness and the treatment awareness. The severity of illness, aggressive impulse control difficulties, psychotic symptoms especially the presence of delusions, female sex may be important predictors of impaired insight.

摘要

目的

本研究旨在探讨双相情感障碍自知力维度与临床特征之间的关系。

方法

104例根据DSM-IV标准诊断为双相情感障碍(躁狂或混合发作)的住院患者参与了本研究。在急性发作期和缓解期,患者在出院前通过杨氏躁狂评定量表(YMRS)、蒙哥马利-阿斯伯格抑郁评定量表(MADRS)、阳性和阴性症状量表(PANSS)、精神障碍自知力量表(SUMD)以及一份关于人口统计学和临床特征的问卷进行评估。

结果

缓解期,57例患者(54.8%)对自己的病情有自知力,而14例(13.5%)没有自知力。此外,6.7%的患者对药物治疗效果缺乏自知力。我们还发现27.9%的患者未意识到疾病的社会后果。有精神病性症状的患者对药物治疗效果以及躁狂发作严重程度的自知力水平显著较低。我们发现这些患者存在妄想不自知的情况。就所有SUMD项目而言,女性患者的自知力明显比男性差。住院次数、发作次数或首发发作类型与自知力维度之间未发现相关性。

结论

双相情感障碍患者缺乏自知力并不罕见。自知力评估涉及疾病的不同组成部分和治疗意识。疾病严重程度、攻击冲动控制困难、精神病性症状尤其是妄想的存在、女性性别可能是自知力受损的重要预测因素。

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