Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA.
Pediatrics. 2012 Jan;129(1):62-9. doi: 10.1542/peds.2011-1513. Epub 2011 Dec 5.
To examine trends in preventive asthma medication (PAM) use among children with current asthma in the United States from 1988 to 2008.
We performed a cross-sectional analysis of PAM use among 2499 children aged 1 to 19 years with current asthma using nationally representative data from the National Health and Nutrition Examination Survey (NHANES) during 3 time periods: 1988-1994, 1999-2002, and 2005-2008. PAMs included inhaled corticosteroids, leukotriene receptor antagonists, long-acting β-agonists, mast-cell stabilizers, and methylxanthines.
Among children with current asthma, there was an increase in the use of PAMs from 17.8% (SE: 3.3) in 1988-1994 to 34.9% (SE: 3.3) in 2005-2008 (P < .001 for trend). Adjusting for age, gender, race/ethnicity, and health insurance status, the odds of PAM use were higher in 2005-2008 compared with 1988-1994 (adjusted odds ratio [aOR] = 2.6; 95% confidence interval [CI]: 1.5-4.5). A multivariate analysis, combining all 3 time periods, showed lower use of PAMs among non-Hispanic black (aOR = 0.5 [95% CI: 0.4-0.7]) and Mexican American (aOR = 0.6 [95% CI: 0.4-0.9]) children compared to non-Hispanic white children. PAM use was also lower in 12 to 19 year olds compared with 1 to 5 year olds and also in children who did not have health insurance compared with those who did.
Between 1988 and 2008, the use of PAM increased among children with current asthma. Non-Hispanic black and Mexican American children, adolescents aged 12 to 19 years, and uninsured children with current asthma had lower use of PAM.
研究 1988 年至 2008 年期间，美国当前哮喘儿童中预防性哮喘药物（PAM）使用的趋势。
我们对全国健康和营养检查调查（NHANES）在三个时期的 2499 名 1 至 19 岁当前哮喘儿童使用 PAM 的情况进行了横断面分析：1988-1994 年、1999-2002 年和 2005-2008 年。PAM 包括吸入皮质类固醇、白三烯受体拮抗剂、长效β-激动剂、肥大细胞稳定剂和黄嘌呤衍生物。
在当前患有哮喘的儿童中，PAM 的使用率从 1988-1994 年的 17.8%（SE：3.3）增加到 2005-2008 年的 34.9%（SE：3.3）（趋势 P <.001）。调整年龄、性别、种族/民族和健康保险状况后，与 1988-1994 年相比，2005-2008 年 PAM 使用的几率更高（调整后的优势比[OR] = 2.6；95%置信区间[CI]：1.5-4.5）。一项结合了所有三个时期的多变量分析显示，与非西班牙裔白人相比，非西班牙裔黑人（OR = 0.5[95%CI：0.4-0.7]）和墨西哥裔美国人（OR = 0.6[95%CI：0.4-0.9]）儿童使用 PAM 的比例较低。与 1 至 5 岁儿童相比，12 至 19 岁儿童使用 PAM 的比例也较低，与有保险的儿童相比，没有保险的儿童使用 PAM 的比例也较低。
1988 年至 2008 年间，当前哮喘儿童中 PAM 的使用有所增加。非西班牙裔黑人和墨西哥裔美国儿童、12 至 19 岁青少年以及当前患有哮喘且没有保险的儿童，PAM 的使用率较低。
