Shumilova T E, Shershkov V I, Nozdrachev A D
Zh Evol Biokhim Fiziol. 2011 Sep-Oct;47(5):396-403.
The systemic and peripheral hemodynamics was studied in male white rats under conditions of acute nitrite hypoxia (subcutaneous administration of sodium nitrite at doses of 1, 3, and 5 mg/100 g body mass). By the electrocardiographic, rheographic, and other methods there were recorded the heart rate (HR), minute circulation volume (MCV), cardiac output (CO), skeletal muscle circulation (SMC), brain circulation (BC), and systemic arterial pressure (AP). Nitrite was shown to produce a fast, dose-dependent AP decrease accompanied by a decrease of MCV due to development of bradycardia and a fall of CO. At the phase of the steady hypotension, CO increased due to a significant rise of CO on the background of the continuing bradycardia. The systemic circulatory effects of NaNO2 were found to be accompanied by a redistribution of peripheral circulation in the form of a dose-dependent increase of BC and a sharp fall of MCV. It was shown that 1-1.5 h after the nitrite injection the parameters of systemic and peripheral hemodynamics approached the initial levels. Possible triggering mechanisms of the initial stage of the rat cardiovascular adaptation to conditions of acute nitrite hypoxia are discussed.
在雄性白色大鼠急性亚硝酸盐缺氧（皮下注射剂量为1、3和5mg/100g体重的亚硝酸钠）条件下研究了全身和外周血流动力学。通过心电图、血流图和其他方法记录了心率（HR）、每分循环血量（MCV）、心输出量（CO）、骨骼肌循环（SMC）、脑循环（BC）和全身动脉压（AP）。结果显示，亚硝酸盐会导致AP快速、剂量依赖性降低，同时由于心动过缓的发生和CO下降，MCV也会降低。在稳定低血压阶段，由于持续心动过缓背景下CO显著升高，CO增加。发现NaNO2的全身循环效应伴随着外周循环的重新分布，表现为BC剂量依赖性增加和MCV急剧下降。结果表明，亚硝酸盐注射后1-1.5小时，全身和外周血流动力学参数接近初始水平。讨论了大鼠心血管适应急性亚硝酸盐缺氧条件初始阶段可能的触发机制。
