Zaĭchenko M I, Merzhanova G Kh
Zh Vyssh Nerv Deiat Im I P Pavlova. 2011 Sep-Oct;61(5):615-23.
Selective antagonists of D1 and D2 receptors (SCH 23 390 and raclopride respectively) were injected to rats divided on the basis of preliminary experiments into groups of"self-controlled" (preference of valuable but delayed reinforcement) and "impulsive" (choice of less valuable but immediate reinforcement) animals. Number of omissions of reactions and their latencies were recorded. In "self-controlled" rats, both drugs increased the number of reactions for less valuable immediate reinforcement, i.e., increased impulsiveness, whereas practically did not change the behavior of "impulsive" animals. Introduction of SCH 23 390 to animals ofboth groups increased the number of reaction omissions the effect being stronger in "self-controlled" animals. Raclopride also increased the number of reaction omissions in "self-controlled" rats but only on the next day after the injection. In "impulsive" animals, both drugs increased the latencies of reactions.
分别向大鼠注射D1和D2受体的选择性拮抗剂（分别为SCH 23390和雷氯必利），这些大鼠根据初步实验被分为“自我控制型”（偏好有价值但延迟的强化物）和“冲动型”（选择价值较低但即时的强化物）动物组。记录反应遗漏的次数及其潜伏期。在“自我控制型”大鼠中，两种药物都增加了对价值较低的即时强化物的反应次数，即增加了冲动性，而实际上对“冲动型”动物的行为没有影响。向两组动物注射SCH 23390均增加了反应遗漏的次数，在“自我控制型”动物中效果更强。雷氯必利也增加了“自我控制型”大鼠的反应遗漏次数，但仅在注射后的第二天。在“冲动型”动物中，两种药物都增加了反应潜伏期。
