Kuleshova E P, Merzhanova G Kh, Grigor'ian G A
Zh Vyssh Nerv Deiat Im I P Pavlova. 2006 Sep-Oct;56(5):641-52.
The influence of two selective antagonists of the dopaminergic receptors, raclopride (D2) and SCH 23 390 (D1) on behavior of "impulsive" and "self-controlled" cats was similar directed. A selective blockade of the dopaminergic D1/D2 receptors by use of raclopride and SCH 23 390 changed a behavioural choice strategy of two different by validity and delay reinforcements in impulsive cats, but did not change it substantially in "self-controlled" animals. Increase of doses of raclopride and SCH 23 390 led to decrease of a part of the short-latency and increase of a part of the long-latency reactions (pedal pressings) in a total number of all effective responses. This occurred only in "impulsive" animals, that indicates probably the decrease of impulsive properties of their behaviour. Both compounds did not affect the choice strategy (a low quality immediate vs. a high quality delayed reinforcements) in "self-control" animals, but elicited more errors and inhibitory responses in their behavior. The data obtained are not consistent with the "dopamine" hypothesis, which predicts increase of impulsivity under influence of dopaminergic antagonists. The reasons that might lead to the data obtained are discussed.
两种多巴胺能受体选择性拮抗剂，雷氯必利（D2）和SCH 23390（D1）对“冲动型”和“自控型”猫行为的影响方向相似。使用雷氯必利和SCH 23390对多巴胺能D1/D2受体进行选择性阻断，改变了冲动型猫基于有效性和延迟强化的两种不同行为选择策略，但在“自控型”动物中并未使其发生实质性改变。雷氯必利和SCH 23390剂量的增加导致所有有效反应总数中短潜伏期反应部分减少，长潜伏期反应（踏板按压）部分增加。这种情况仅发生在“冲动型”动物中，这可能表明其行为的冲动性降低。两种化合物均未影响“自控型”动物的选择策略（低质量即时强化与高质量延迟强化），但在其行为中引发了更多错误和抑制性反应。所获得的数据与“多巴胺”假说不一致，该假说预测多巴胺能拮抗剂会增加冲动性。文中讨论了可能导致所获数据的原因。
