University of Leeds, Leeds Teaching Hospitals NHS Trust, School of Medicine, Academic Dept. of Trauma and Orthopaedics, Leeds, UK.
Expert Opin Drug Saf. 2012 Mar;11(2):215-20. doi: 10.1517/14740338.2012.639359. Epub 2011 Dec 6.
Over 39,000 diabetic patients are surgically treated for trauma and orthopaedic injuries annually in the UK, yet the effects of diabetic medications on the skeletal system is an under researched and under acknowledged field.
This review covers all English language novel experimental data reports investigating the effects of the main classes of diabetic drugs on the skeletal system, specifically their effects on fracture healing, located through the literature search engines Medline and Web of Science.
Post-surgical gylcaemic control is paramount in insulin-controlled type 1 diabetic patients. Data on pharmacological control compounds used in type 2 diabetes are limited. Reports to date indicate thiazolidinediones to exert anti-osteogenic effects, in contrast to the observed osteogenic effects of biguanides. Ongoing research is desirable to guide future clinical recommendations.
在英国，每年有超过 39000 名糖尿病患者因创伤和骨科损伤接受手术治疗，但糖尿病药物对骨骼系统的影响是一个研究和认识不足的领域。
本综述涵盖了所有英语新的实验数据报告，这些报告调查了主要类别的糖尿病药物对骨骼系统的影响，特别是它们对骨折愈合的影响，通过文献检索引擎 Medline 和 Web of Science 进行了定位。
手术后的血糖控制对 1 型糖尿病患者至关重要。关于 2 型糖尿病中使用的药物控制化合物的数据有限。迄今为止的报告表明，噻唑烷二酮类药物具有抗成骨作用，而双胍类药物则观察到成骨作用。需要进行正在进行的研究，以指导未来的临床建议。
