University of Florence, Bone Metabolic Diseases Unit, Department of Surgery and Translational Medicine, Florence, Italy.
Expert Opin Pharmacother. 2013 Aug;14(11):1441-7. doi: 10.1517/14656566.2013.801959. Epub 2013 Jun 17.
Fracture healing is a complex process that leads to the restoration of tissue integrity through bone repair and represents a unique physiological characteristic of bone. Developing a better understanding of a fracture is essential to plan best noninvasive treatment for the patient. In osteoporosis, the patient who suffers of a fragility fracture is recommended to initiate a treatment with compounds active in preventing other low-energy skeletal trauma. Pharmaceutical industries are developing controlled clinical trials aiming to evaluate the capability of osteoporosis drugs to accelerate fracture healing.
In preparing this review, a search was made with key words encompassing 'osteoporosis anti-fracture drugs and bone repair/healing', 'antiresorptives and bone repair/healing', 'bone-forming agents and bone repair/healing', and 'osteoporosis/anti-fracture drugs in fractures'. The results published in the area of the use of registered anti-fracture drugs to improve fracture repair and the efforts made to recommend measures for clinical outcomes in fracture healing acceleration are described in this report.
At present, the use of systemic pharmacological agents active to improve fracture healing by the clinicians is controversial and clinicians and scientists must do a better job in determining the methods of assessment for fracture healing.
骨折愈合是一个复杂的过程，通过骨修复恢复组织完整性，代表了骨骼的独特生理特性。更好地了解骨折对于为患者制定最佳非侵入性治疗方案至关重要。在骨质疏松症中，建议患有脆性骨折的患者开始使用预防其他低能量骨骼创伤的活性化合物进行治疗。制药行业正在开展对照临床试验，旨在评估骨质疏松症药物加速骨折愈合的能力。
在编写本综述时，使用了包含“骨质疏松症抗骨折药物和骨修复/愈合”、“抗吸收剂和骨修复/愈合”、“成骨剂和骨修复/愈合”和“骨质疏松症/抗骨折药物在骨折中的应用”等关键词进行了搜索。本报告描述了在使用已注册的抗骨折药物来改善骨折修复方面所取得的成果，以及为加速骨折愈合推荐临床结果措施方面所做的努力。
目前，临床医生使用全身性药物来改善骨折愈合的效果存在争议，临床医生和科学家必须更好地确定骨折愈合评估方法。
