Davydova I V, Andrusenko A B
Klin Med (Mosk). 1990 Jun;68(6):115-9.
Lymphocytic levels of glucocorticoid receptors were evaluated in 114 patients suffering from Icenko-Cushing's syndrome. Incidence of HLA antigens was determined in 94 of them. A significant rise of A10 and B27 antigen incidence compared to that in normal subjects allows these antigens to be considered genetic markers of Icenko-Cushing's syndrome. The levels of glucocorticoid receptors in lymphocytes of the patients are lower than in normal subjects both in the active stage of the disease and following bilateral total adrenalectomy. The patients carrying B27 antigen had lymphocytic receptor concentrations under the levels of such in patients free of the antigen carriage. Antigen B27 seems to be a cause of lower levels of glucocorticoid receptors in blood lymphocytes.
对114例艾申科-库欣综合征患者的淋巴细胞糖皮质激素受体水平进行了评估。其中94例患者测定了HLA抗原的发生率。与正常受试者相比，A10和B27抗原发生率显著升高，这使得这些抗原可被视为艾申科-库欣综合征的遗传标记。无论是在疾病的活动期还是双侧肾上腺全切术后，患者淋巴细胞中的糖皮质激素受体水平均低于正常受试者。携带B27抗原的患者淋巴细胞受体浓度低于未携带该抗原的患者。抗原B27似乎是血液淋巴细胞中糖皮质激素受体水平较低的原因。
