Manishkina R P, Andrusenko A B, Donskov S I, Kalinin A P, Klinova E G
Ter Arkh. 1984;56(8):133-5.
The determination of HLA antigens in 54 patients with Icenko-Cushing's disease demonstrated the high rate of AIO antigens (50.7%), B8 (27.3%) and B27 (26.2%) antigens. In the control group, the rate of the same antigens amounted to 17.8, 16.3 and 7.4%, respectively. Specific features were also revealed in the rate of individual HLA haplotypes. The rate of A X IO, B8; A X IO, B27 haplotypes occurring relatively rarely in normal subjects was high in patients with Icenko-Cushing's disease. The high rate of AIO, B8 and B27 antigens may attest to the high risk of the development of Icenko-Cushing's disease in subjects carrying these antigens.
对54例伊兴科-库欣病患者进行的HLA抗原测定显示，AIO抗原（50.7%）、B8（27.3%）和B27（26.2%）抗原的出现率较高。在对照组中，相同抗原的出现率分别为17.8%、16.3%和7.4%。在个体HLA单倍型的出现率方面也发现了一些特点。在正常人群中相对少见的A X IO、B8；A X IO、B27单倍型，在伊兴科-库欣病患者中的出现率较高。AIO、B8和B27抗原的高出现率可能证明携带这些抗原的个体患伊兴科-库欣病的风险较高。
