Department of Gastroenterology and Hepatology, Molinette Hospital, Turin, Italy.
Panminerva Med. 2011 Dec;53(4):213-6.
Celiac disease (CD) is a chronic, immune-mediated disorder, characterized by small intestinal malabsorption of nutrients after the ingestion of gluten by genetically susceptible individuals. The discovery of the wide variations in the nature and intensity of clinical presentation of CD has transformed its status, long considered a rare disease, to that of a common health problem. As patients with CD get older, they tend to present with complaints not directly referable to the gastrointestinal tract. Neurologic symptoms, caused by lesions of the central or peripheral nervous system occasionally occur in patients with CD and are poorly understood. This review focalizes on the present knowledge of the potential relationship between CD and epilepsy. The prevalence of CD among patients with epilepsy is not homogeneously distributed, probably because epilepsy encompasses a heterogeneous group of disorders. In fact, the clinical spectrum of epilepsy related to CD ranges from benign syndromes to intractable epilepsy. The precise mechanism of the potential association between CD and epilepsy is also still under discussion.
乳糜泻（CD）是一种慢性、免疫介导的疾病，其特征是在遗传易感个体摄入麸质后，小肠对营养物质的吸收不良。对 CD 临床表现的性质和强度的广泛变化的发现，使其从一种罕见疾病转变为常见的健康问题。随着 CD 患者年龄的增长，他们往往会出现与胃肠道无关的症状。中枢或周围神经系统病变偶尔会导致 CD 患者出现神经症状，但这些症状的了解还很有限。这篇综述聚焦于目前对 CD 与癫痫之间潜在关系的认识。癫痫患者中 CD 的患病率分布不均，可能是因为癫痫包括一组异质性疾病。事实上，与 CD 相关的癫痫临床谱从良性综合征到难治性癫痫不等。CD 和癫痫之间潜在关联的确切机制仍在讨论中。
