Department of Gastro-Hepatology, Molinette Hospital, C.so Bramante 88, 10126 Turin, Italy.
Nutrients. 2013 Aug 22;5(9):3329-36. doi: 10.3390/nu5093329.
Celiac disease is a chronic, immune-mediated disorder, characterized by small intestinal inflammation and villous atrophy after the ingestion of gluten by genetically susceptible individuals. Several extraintestinal manifestations have been associated to celiac disease. Eosinophilic esophagitis is a primary disorder of the esophagus characterized by upper gastrointestinal symptoms, absence of gastroesophageal reflux disease and more than 15 eosinophils per high-power field in biopsy specimens. Both celiac disease and eosinophilic esophagitis are caused by aberrant, but distinct, immune responses to ingested antigens and can be responsive to restricted food intake. The aim of this review is to assess whether there is an association between these two pathologies. In the majority of the studies examined, including the studies in pediatric population, the prevalence of eosinophilic esophagitis in subjects with celiac disease was about 10-times that of the general population. We suggest searching for eosinophilic esophagitis in all children undergoing endoscopy for suspicious celiac disease.
乳糜泻是一种慢性、免疫介导的疾病，其特征是在遗传易感个体摄入麸质后，小肠炎症和绒毛萎缩。乳糜泻与几种肠外表现有关。嗜酸性食管炎是一种主要的食管疾病，其特征是上消化道症状、无胃食管反流病和活检标本中每高倍视野超过 15 个嗜酸性粒细胞。乳糜泻和嗜酸性食管炎都是由摄入的抗原引起的异常但不同的免疫反应引起的，并且可以对限制饮食有反应。本综述的目的是评估这两种病理之间是否存在关联。在大多数检查的研究中，包括儿科人群的研究，乳糜泻患者中嗜酸性食管炎的患病率是普通人群的约 10 倍。我们建议在所有因疑似乳糜泻而行内镜检查的儿童中寻找嗜酸性食管炎。
