College of Fisheries, Huazhong Agriculture University, Wuhan, Hubei 430070, China.
Fish Shellfish Immunol. 2012 Feb;32(2):301-6. doi: 10.1016/j.fsi.2011.11.019. Epub 2011 Nov 27.
Heme oxygenase (HO-1) is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes. In mammalian systems, viral infection or antigen expression can down-regulate the expression of HO-1. In turn, the induction of HO-1 or overexpression of HO-1 results in potent and direct antiviral activity that targets the replication of several mammalian viruses. In this study, the HO-1 gene of Cyprinus carpio was cloned, and the expression profile of HO-1 was investigated during spring viremia of carp virus (SVCV) infection. The results demonstrate that the expression of HO-1 was down-regulated during SVCV infection in the EPC cells and in common carp. These results indicated that SVCV infection could induce host oxidative stress, which may contribute to tissue injury in affect fish.
血红素加氧酶（HO-1）是一种细胞保护性酶，在炎症过程中抵抗氧化剂诱导的损伤方面起着关键作用。在哺乳动物系统中，病毒感染或抗原表达可以下调 HO-1 的表达。相反，HO-1 的诱导或 HO-1 的过表达导致针对几种哺乳动物病毒复制的有效和直接的抗病毒活性。在这项研究中，鲤鱼的 HO-1 基因被克隆，并研究了 HO-1 在鲤鱼病毒血症（SVCV）感染期间的表达谱。结果表明，在 EPC 细胞和鲤鱼中，SVCV 感染期间 HO-1 的表达下调。这些结果表明，SVCV 感染可诱导宿主氧化应激，这可能导致受感染鱼类的组织损伤。
