Department of Pediatrics, University Children's Hospital Münster, Münster, Germany.
Pediatr Blood Cancer. 2012 Oct;59(4):621-6. doi: 10.1002/pbc.24001. Epub 2011 Dec 6.
Objective of our study was to evaluate the nutritional status and growth of children and adolescents with common malignancies of the musculoskeletal system at diagnosis, and undergoing multimodality therapy.
A retrospective analysis of data from 2001 to 2009 was conducted. Hospital charts were used as a source of clinical data. Primary endpoint of the analyses was to identify variations in anthropometric parameters at diagnosis and during the first 2 years of follow-up in children and adolescents with osteosarcoma or Ewing sarcoma. Factors contributing to disorders of growth in this population were sought.
A total of 139 children were registered, 62 with Ewing sarcoma and 77 with osteosarcoma. At diagnosis 72.7% of all patients were classified as adequately nourished (BMI 5th to <85th percentiles). During treatment all anthropometric parameters were markedly reduced (P < 0.001) in both groups with extreme changes in body weight from -30% to +44%. This was pronounced in children affected by osteosarcoma (P < 0.05). During follow-up, recovery of body weight was noted in both groups. Height Z-scores remained low (P < 0.001) in comparison to the general population. After the observation period 43.4% of the children with osteosarcoma and 25.5% of the patients with Ewing sarcoma demonstrated an altered body mass.
Pediatric patients with Ewing sarcoma or osteosarcoma are at an increased risk for developing malnutrition, in the form of either over- or underweight during multimodality therapy. Early recognition of abnormal body mass is required to prevent and to treat long-term comorbidities caused by malnutrition.
我们研究的目的是评估患有常见骨与软组织恶性肿瘤儿童和青少年在诊断时及接受多模式治疗后的营养状况和生长情况。
对 2001 年至 2009 年的数据进行回顾性分析。使用医院病历作为临床数据的来源。分析的主要终点是确定骨肉瘤或尤文肉瘤患儿在诊断时和随访的前 2 年内，人体测量参数的变化。寻找导致该人群生长障碍的因素。
共登记了 139 名儿童，其中 62 名为尤文肉瘤，77 名为骨肉瘤。在诊断时，所有患者中有 72.7%被归类为营养充足（BMI 第 5 百分位至<85 百分位）。在治疗过程中，两组的所有人体测量参数均明显降低（P <0.001），体重变化范围从-30%到+44%。骨肉瘤患儿的变化更为明显（P <0.05）。在随访期间，两组的体重均有所恢复。与一般人群相比，身高 Z 评分仍然较低（P <0.001）。在观察期结束时，43.4%的骨肉瘤患儿和 25.5%的尤文肉瘤患儿的体重发生改变。
接受多模式治疗的尤文肉瘤或骨肉瘤患儿存在发生营养不良的风险，表现为超重或体重不足。需要早期识别异常体重，以预防和治疗由营养不良引起的长期并发症。
