Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd NE, Atlanta, GA 30322, USA.
J Nucl Cardiol. 2012 Feb;19(1):92-9. doi: 10.1007/s12350-011-9438-0. Epub 2011 Dec 7.
The purpose of this study was to evaluate global quantitation of cardiac uptake on I-123 mIBG SPECT.
The study included a pilot group of 67 subjects and a validation group of 1,051 subjects. SPECT images were reconstructed by filtered backprojection, ordered subsets expectation maximization, and deconvolution of septal penetration, respectively. SPECT heart-to-mediastinum ratio (H/M) was calculated by comparing the mean counts between heart and mediastinum volumes of interest drawn on transaxial images. Receiver operating characteristic (ROC) analysis was used to assess the capability of each SPECT method to differentiate the heart disease subjects from controls in comparison with that of the planar H/M.
In the validation group, the areas under the ROC curves were not significantly different between the SPECT and planar H/M. Order subsets expectation maximization had significantly larger area under the ROC curve than the other two SPECT methods.
H/M obtained from I-123 mIBG SPECT was equivalent to the planar H/M for differentiating between subjects with normal and abnormal mIBG uptake. Global quantification of cardiac I-123 mIBG SPECT may represent a viable alternative to the planar H/M.
本研究旨在评估 I-123 mIBG SPECT 对心脏摄取的全球定量。
该研究包括 67 名受试者的试点组和 1051 名受试者的验证组。分别通过滤波反投影、有序子集期望最大化和隔室穿透的反卷积重建 SPECT 图像。通过比较感兴趣区在轴位图像上的心脏和纵隔之间的平均计数，计算 SPECT 心脏与纵隔比（H/M）。使用接收者操作特性（ROC）分析评估每种 SPECT 方法与平面 H/M 相比区分心脏病患者和对照者的能力。
在验证组中，SPECT 和平面 H/M 的 ROC 曲线下面积之间没有显著差异。有序子集期望最大化的 ROC 曲线下面积明显大于其他两种 SPECT 方法。
I-123 mIBG SPECT 获得的 H/M 对于区分正常和异常 mIBG 摄取的患者具有等效性。心脏 I-123 mIBG SPECT 的全局定量可能是平面 H/M 的可行替代方案。
