一种由唑类抗真菌药物诱导产生的新型羊毛甾醇异构体。

A novel lanosterol isomer produced in response to azole antifungals.

作者信息

Howell S A, Mallet A I

机构信息

Institute of Dermatology, UMDS, St Thomas' Hospital, London, England.

出版信息

J Steroid Biochem. 1990 Aug 14;36(5):505-6. doi: 10.1016/0022-4731(90)90095-a.

DOI:10.1016/0022-4731(90)90095-a

PMID:2214765

Abstract

Gas chromatography-mass spectrometry has revealed the existence of a novel lanosterol-like sterol which is produced by fungi in response to treatment with azole drugs. The significance of this finding may be related to the changes in fungal sterol synthesis as a consequence to prolonged exposure to azoles and consequent development of resistance to these agents.

摘要

气相色谱-质谱分析揭示了一种新型羊毛甾醇样甾醇的存在，这种甾醇是真菌在接受唑类药物治疗时产生的。这一发现的意义可能与长期接触唑类药物导致真菌甾醇合成的变化以及随后对这些药物产生耐药性有关。