Defective sterol delta 5(6) desaturase as a cause of azole resistance in Ustilago maydis.
作者信息
Joseph-Horne T, Manning N J, Hollomon D, Kelly S L
机构信息
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, UK.
出版信息
FEMS Microbiol Lett. 1995 Mar 15;127(1-2):29-34. doi: 10.1111/j.1574-6968.1995.tb07445.x.
Abstract
Resistance to azole antifungals in Ustilago maydis was associated with a leaky defect in sterol delta 5(6)desaturase. This defect resulted in reduced accumulation of 14 alpha-methylergosta-24(28)-diene-3 beta,6 alpha-diol and an increase in the proportion of 14 alpha-methylfecosterol in treated cells when compared to the parent strain. The results demonstrate the importance of this mechanism in pathogenic fungi.
摘要
Zotero 插件