特发性快动眼睡眠行为障碍患者的 13C-辛酸呼气试验显示胃动力正常。
Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test.
机构信息
Department of Neurology, Philipps-University Marburg, Marburg, Germany.
出版信息
Mov Disord. 2011 Dec;26(14):2559-63. doi: 10.1002/mds.23933. Epub 2011 Aug 24.
BACKGROUND
Delayed gastric emptying is a non-motor symptom of Parkinson's disease. Few data exist on gastric emptying in early-stage Parkinson's disease. In idiopathic rapid-eye-movement sleep behavior disorder, a presumable pre-motor stage of Parkinson's disease, gastric emptying has not yet been investigated.
METHODS
Twenty healthy controls, 13 patients with idiopathic rapid-eye-movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the (13)C-octanoate breath test.
RESULTS
Gastric emptying was significantly delayed in drug-naïve (P < .001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid-eye-movement sleep behavior disorder.
CONCLUSIONS
Our study confirms delayed gastric emptying in drug-naïve, early-stage Parkinson's disease. Normal gastric emptying in idiopathic rapid-eye-movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the (13)C-octanoate breath test.
背景
胃排空延迟是帕金森病的一种非运动症状。关于早期帕金森病患者的胃排空情况的数据很少。在特发性快速眼动睡眠行为障碍中，这是帕金森病的一个假定的运动前期，尚未对胃排空进行研究。
方法
20 名健康对照者、13 名特发性快速眼动睡眠行为障碍患者和 39 名帕金森病患者接受了（13）C-辛酸呼气试验的标准化胃排空测试。
结果
在未接受药物治疗的帕金森病患者（P<0.001）和接受药物治疗的帕金森病患者（P<0.001）中，胃排空明显延迟，但特发性快速眼动睡眠行为障碍患者的胃排空正常。
结论
我们的研究证实了未经药物治疗的早期帕金森病患者胃排空延迟。特发性快速眼动睡眠行为障碍患者胃排空正常可能是因为调节胃动力的结构的神经退行性变化还不够严重，不足以导致功能性缺陷，无法通过（13）C-辛酸呼气试验检测到。
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