Department of Medicine II, Institute of Endocrinology and Hypertension, Tokyo Women's Medical University, Japan.
J Renin Angiotensin Aldosterone Syst. 2011 Dec;12(4):638-40. doi: 10.1177/1470320311429227.
The (pro)renin receptor (P)RR is a receptor for renin and prorenin, not only allowing local production of angiotensin I from angiotensinogen, but also inducing intracellular signaling. Intriguingly, (P)RR is also called ATP6AP2 because a (P)RR fragment was demonstrated to be associated with vacuolar-type H+-ATPase (V-ATPase), which is of importance for the maintenance of intracellular pH. Recent studies implicate that deletion of (P)RR results in the dysfunction of V-ATPase, suggesting that the (P)RR is essential for its role as a proton pump. Furthermore, the novel function of (P)RR as an adaptor protein between the Wnt receptor complex and the V-ATPase was discovered. Thus, (P)RR is a multi-functional molecule with functions beyond renin and prorenin. This review focuses on the current knowledge and issues of (P)RR and V-ATPase.
（前）肾素受体（P）RR 是肾素和前肾素的受体，不仅允许局部从血管紧张素原产生血管紧张素 I，还诱导细胞内信号转导。有趣的是，（P）RR 也被称为 ATP6AP2，因为已经证明（P）RR 片段与液泡型 H+-ATP 酶（V-ATPase）相关，这对于维持细胞内 pH 值很重要。最近的研究表明，（P）RR 的缺失会导致 V-ATPase 的功能障碍，这表明（P）RR 对于其作为质子泵的作用是必不可少的。此外，还发现了（P）RR 作为 Wnt 受体复合物与 V-ATPase 之间衔接蛋白的新功能。因此，（P）RR 是一种具有超越肾素和前肾素功能的多功能分子。本综述重点介绍了（P）RR 和 V-ATPase 的最新知识和问题。
