肠激酶和胰蛋白酶对胰蛋白酶原的激活动力学。
Kinetics of the trypsinogen activation by enterokinase and trypsin.
作者信息
Varón R, Havsteen B H, Vázquez A, García M, Valero E, García Cánovas F
机构信息
Biochemisches Institut, Christian Albrechts Universität zu Kiel, West Germany.
出版信息
J Theor Biol. 1990 Jul 9;145(1):123-31. doi: 10.1016/s0022-5193(05)80538-7.
A global kinetic analysis of the mechanisms of the trypsinogen activation by enterokinase and trypsin is presented. The kinetic equations of both the transient-phase and the steady-state of these mechanisms are presented. In addition, we here derive the corresponding kinetic equations for the case in which the condition of rapid equilibrium prevails and we propose a kinetic data analysis. The significance of this approach to the treatment of other zymogen activation processes is discussed.
本文对肠激酶和胰蛋白酶激活胰蛋白酶原的机制进行了全局动力学分析。给出了这些机制的瞬态相和稳态的动力学方程。此外，我们在此推导了快速平衡条件占优情况下的相应动力学方程，并提出了一种动力学数据分析方法。讨论了这种方法对处理其他酶原激活过程的意义。
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